Micro- and nanolattices can achieve simultaneously both lightweight and ultra-high strength due to a combination of resilient architecture and enhanced mechanical properties of small-scale unit constituents. However, understanding the fundamental deformation mechanism for these novel materials remains intriguing due to the intricate interplay of various geometric characteristics and intrinsic microscopic defects. Here, we investigate the fundamental mechanism of plastic deformation in terms of dynamic evolution of defects and corresponding mechanical responses in aluminum nanolattices using a mesoscale defect dynamics model which couples three-dimensional dislocation dynamics and finite element method. Our concurrently coupled model could capture detailed dislocation motion under complex loading conditions and predict the plastic flow stress of the nanolattices. We demonstrate that the size of individual constituent beam plays a critical role in the properties of nanolattices through small-scale strengthening, showing the strength of the nanolattices increases with decreasing beam size with the scaling law of σ∝d^0.89. As a result, the scaling law of plastic yielding with material density drastically increases from the continuum prediction. In addition, our modeling could allow us to study the geometric effect with various nanolattices. These findings establish a foundation for the fundamental understanding of the governing mechanism of plastic deformation, allowing access to a new regime in designing optimal structures using nanolattices.